InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EXOSC8

Summary

InnateDB Protein

IDBP-24723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXOSC8

Protein Name

exosome component 8

Synonyms

bA421P11.3; CIP3; EAP2; OIP2; p9; RRP43; Rrp43p;

Species

Homo sapiens

Ensembl Protein

ENSP00000374354

InnateDB Gene

IDBG-24717 (EXOSC8)

Protein Structure

UniProt Annotation

Function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs. {ECO:0000269PubMed:16912217, ECO:0000269PubMed:17545563}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17545563}. Nucleus {ECO:0000269PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017091	AU-rich element binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006364	rRNA processing
GO:0008150	biological_process
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

Cellular Component

GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001247 Exoribonuclease, phosphorolytic domain 1
IPR015847 Exoribonuclease, phosphorolytic domain 2
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF01138
PF03725

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96B26

PhosphoSite