InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nox3

Summary

InnateDB Protein

IDBP-248839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nox3

Protein Name

NADPH oxidase 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111466

InnateDB Gene

IDBG-132764 (Nox3)

Protein Structure

UniProt Annotation

Function

NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. {ECO:0000269PubMed:15014044, ECO:0000269PubMed:15326186}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in inner ear by the spiral glanglion neurons, the vestibular system and the sensory epithelial cell layer of the saccule. Weakly expressed in skull and brain. {ECO:0000269PubMed:15326186}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0001659	temperature homeostasis
GO:0009590	detection of gravity
GO:0009629	response to gravity
GO:0042554	superoxide anion generation
GO:0048840	otolith development
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0043020	NADPH oxidase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2681162

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q672J9