InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Paip2

Summary

InnateDB Protein

IDBP-248989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Paip2

Protein Name

polyadenylate-binding protein-interacting protein 2

Synonyms

2310050K10Rik; AU045972;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111400

InnateDB Gene

IDBG-136928 (Paip2)

Protein Structure

UniProt Annotation

Function

Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003729	mRNA binding
GO:0008143	poly(A) binding

Biological Process

GO:0006417	regulation of translation
GO:0007283	spermatogenesis
GO:0007613	memory
GO:0017148	negative regulation of translation
GO:0045947	negative regulation of translational initiation
GO:1900271	regulation of long-term synaptic potentiation