InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zglp1

Summary

InnateDB Protein

IDBP-249514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zglp1

Protein Name

zinc finger, GATA-like protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111157

InnateDB Gene

IDBG-249512 (Zglp1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function. {ECO:0000269PubMed:16982049}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16982049}.

Disease Associations

Tissue Specificity

Specifically expressed in adult testis and ovary. Expressed at high levels in the somatic cells of the developing gonads, including Leydig cells in the testes and granulosa cells in the ovaries. {ECO:0000269PubMed:16982049}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0048599	oocyte development