InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccnf

Summary

InnateDB Protein

IDBP-249744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccnf

Protein Name

cyclin F

Synonyms

CycF; Fbxo1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111048

InnateDB Gene

IDBG-145650 (Ccnf)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000320	re-entry into mitotic cell cycle
GO:0001890	placenta development
GO:0007067	mitotic nuclear division
GO:0010826	negative regulation of centrosome duplication
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process