Version 5.4
Homo sapiens Protein: POSTN
Summary
InnateDB Protein IDBP-24979.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POSTN
Protein Name periostin, osteoblast specific factor
Synonyms OSF-2; OSF2; PDLPOSTN; periostin; PN;
Species Homo sapiens
Ensembl Protein ENSP00000369066
InnateDB Gene IDBG-24971 (POSTN)
Protein Structure
UniProt Annotation
Function Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. {ECO:0000250, ECO:0000269PubMed:12235007, ECO:0000269PubMed:18450759}.
Subcellular Localization Golgi apparatus {ECO:0000250}. Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:12235007}. Note=Colocalizes with BMP1 in the Golgi. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. {ECO:0000269PubMed:11550156, ECO:0000269PubMed:12235007, ECO:0000269PubMed:15082792, ECO:0000269PubMed:23946676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0001501 skeletal system development
GO:0007155 cell adhesion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005802 trans-Golgi network
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR000782 FAS1 domain
IPR011489 EMI domain
IPR016666 TGF beta-induced protein bIGH3/osteoblast-specific factor 2
PFAM PF02469
PF07546
PRINTS
PIRSF PIRSF016553
SMART SM00554
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15063
PhosphoSite PhosphoSite-Q15063
TrEMBL A0A024RDT5
UniProt Splice Variant
Entrez Gene 10631
UniGene Hs.721018
RefSeq NP_001129406
HUGO HGNC:16953
OMIM 608777
CCDS CCDS45034
HPRD 12295
IMGT
EMBL AL138679 AL646087 AY140646 AY918092 BC106709 BC106710 CH471075 D13665 D13666 EU262883 EU262884 EU262886 GU354210
GenPept AAI06710 AAI06711 AAN17733 AAY15840 ABY86630 ABY86631 ABY86633 ADA79517 BAA02836 BAA02837 CAH70104 CAH70107 CAH73568 CAH73569 EAX08590 EAX08591

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca