InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cadps2

Summary

InnateDB Protein

IDBP-249796.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cadps2

Protein Name

Ca2+-dependent activator protein for secretion 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111013

InnateDB Gene

IDBG-129779 (Cadps2)

Protein Structure

UniProt Annotation

Function

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, synapse {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.

Disease Associations

Tissue Specificity

Highly expressed in cerebellum. Also expressed in non-neuronal tissues such as lung, spleen, testis, uterus and ovary. Highly expressed in brain. In brain, it is highly expressed in cerebellum, cortex, olfactory bulb, CA1/CA2 regions of the hippocampus, and dentate gyrus, and weakly or not expressed in the CA3 regions of the hippocampus, striatum, thalamus, superior and inferior colliculi, and brain stem. Not present in adult adrenal glands. Isoform 4, but not isoform 3, is highly expressed in postnatal and adult stages of cerebellum. {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0046872	metal ion binding

Biological Process

GO:0009267	cellular response to starvation
GO:0015031	protein transport
GO:0016082	synaptic vesicle priming
GO:0045921	positive regulation of exocytosis

Cellular Component

GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0042734	presynaptic membrane
GO:0045211	postsynaptic membrane