InnateDB Protein
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IDBP-249798.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cadps2
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Protein Name
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Ca2+-dependent activator protein for secretion 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111012
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InnateDB Gene
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IDBG-129779 (Cadps2)
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Protein Structure
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Function |
Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles.
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Subcellular Localization |
Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, synapse {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles.
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Disease Associations |
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Tissue Specificity |
Highly expressed in cerebellum. Also expressed in non-neuronal tissues such as lung, spleen, testis, uterus and ovary. Highly expressed in brain. In brain, it is highly expressed in cerebellum, cortex, olfactory bulb, CA1/CA2 regions of the hippocampus, and dentate gyrus, and weakly or not expressed in the CA3 regions of the hippocampus, striatum, thalamus, superior and inferior colliculi, and brain stem. Not present in adult adrenal glands. Isoform 4, but not isoform 3, is highly expressed in postnatal and adult stages of cerebellum. {ECO:0000269PubMed:14530279, ECO:0000269PubMed:15820695}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443963
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BYR5
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PhosphoSite |
PhosphoSite-Q8BYR5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
320405
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UniGene |
Mm.489948
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RefSeq |
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MGI ID |
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MGI Symbol |
Cadps2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB098623
AF000969
AK038568
AK042634
AK046596
AY072800
BC047394
BC055462
BC059274
BC080854
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GenPept |
AAB58720
AAH47394
AAH55462
AAH59274
AAH80854
AAL67937
BAC30047
BAC31314
BAC32801
BAD05017
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