InnateDB Protein
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IDBP-249825.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tceb1
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Protein Name
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transcription elongation factor B (SIII), polypeptide 1
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Synonyms
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2610043E24Rik; 2610301I15Rik; AA407206; AI987979; AW049146;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111009
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InnateDB Gene
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IDBG-249823 (Tceb1)
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Protein Structure
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Function |
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
113 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0032968
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positive regulation of transcription elongation from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
MGI:1915173
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InterPro |
IPR001232
SKP1 component
IPR011333
BTB/POZ fold
IPR016073
SKP1 component, POZ domain
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PFAM |
PF03931
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PRINTS |
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PIRSF |
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SMART |
SM00512
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TIGRFAMs |
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Modification |
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SwissProt |
P83940
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PhosphoSite |
PhosphoSite-P83940
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67923
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UniGene |
Mm.399216
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RefSeq |
XP_006543684
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MGI ID |
4JGH
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MGI Symbol |
Tceb1
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OMIM |
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CCDS |
CCDS35517
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HPRD |
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IMGT |
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EMBL |
AK011757
AK011958
AK012909
AK013089
AK039746
BC009104
BC028545
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GenPept |
AAH09104
AAH28545
BAB27825
BAB27939
BAB28546
BAB28641
BAC30437
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