Mus musculus Protein: Csf1r
InnateDB Protein IDBP-250008.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csf1r
Protein Name colony stimulating factor 1 receptor
Synonyms AI323359; CD115; CSF-1R; Csfmr; Fim-2; Fms; M-CSF-R; M-CSFR;
Species Mus musculus
Ensembl Protein ENSMUSP00000110923
InnateDB Gene IDBG-150998 (Csf1r)
Protein Structure
UniProt Annotation
Function Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. {ECO:0000269PubMed:10958675, ECO:0000269PubMed:11756160, ECO:0000269PubMed:1652061, ECO:0000269PubMed:16950670, ECO:0000269PubMed:17353186, ECO:0000269PubMed:17420255, ECO:0000269PubMed:17420256, ECO:0000269PubMed:17972959, ECO:0000269PubMed:18814279, ECO:0000269PubMed:20181277, ECO:0000269PubMed:20504948, ECO:0000269PubMed:21610095, ECO:0000269PubMed:21727904, ECO:0000269PubMed:8007983, ECO:0000269PubMed:8262059, ECO:0000269PubMed:9312046}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:17353186, ECO:0000269PubMed:8007983}; Single-pass type I membrane protein {ECO:0000269PubMed:17353186, ECO:0000269PubMed:8007983}. Note=The autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:20504948}.
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 28 [view]
Protein-DNA 2 [view]
Protein-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005011 macrophage colony-stimulating factor receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019903 protein phosphatase binding
GO:0019955 cytokine binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008360 regulation of cell shape
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0031529 ruffle organization
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0038145 macrophage colony-stimulating factor signaling pathway
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045087 innate immune response (InnateDB)
GO:0045124 regulation of bone resorption
GO:0045217 cell-cell junction maintenance
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090197 positive regulation of chemokine secretion
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:1339758
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR016243 Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
Post-translational Modifications
SwissProt P09581
PhosphoSite PhosphoSite-P09581
UniProt Splice Variant
Entrez Gene 12978
UniGene Mm.443838
RefSeq XP_006525647
MGI Symbol Csf1r
EMBL AK004947 AK079247 AK143545 AK154653 BC036343 BC043054 CH466528 S62219 X06368
GenPept AAH36343 AAH43054 BAB23691 BAC37587 BAE25430 BAE32744 CAA29666 EDL09786