InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sept6

Summary

InnateDB Protein

IDBP-250071.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sept6

Protein Name

septin 6

Synonyms

2810035H17Rik; C920001C06Rik; mKIAA0128; Sep6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110894

InnateDB Gene

IDBG-138528 (Sept6)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Associated with synaptic vesicles in various brain regions, including glomeruli of the olfactory bulb. {ECO:0000269PubMed:11064363}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0007049	cell cycle
GO:0051301	cell division

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005819	spindle
GO:0008021	synaptic vesicle
GO:0030496	midbody
GO:0031105	septin complex
GO:0032154	cleavage furrow
GO:0043679	axon terminus