Version 5.4
Mus musculus Protein: 1700021K19Rik
Summary
InnateDB Protein IDBP-250351.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 1700021K19Rik
Protein Name RIKEN cDNA 1700021K19 gene
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000110757
InnateDB Gene IDBG-154810 (1700021K19Rik)
Protein Structure
UniProt Annotation
Function Negatively regulates endocytic trafficking. Impairs the autophagosome maturation process. May inhibit PIK3C3 activity. {ECO:0000269PubMed:19270693}.
Subcellular Localization Late endosome {ECO:0000269PubMed:19270693}. Lysosome {ECO:0000269PubMed:19270693}. Early endosome {ECO:0000269PubMed:19270693}. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endososome and not at all in the Golgi apparatus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0010507 negative regulation of autophagy
GO:0045087 innate immune response (InnateDB)
GO:0045806 negative regulation of endocytosis
Cellular Component
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:1915160
InterPro IPR004012 RUN
PFAM PF02759
PRINTS
PIRSF
SMART SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80U62
PhosphoSite PhosphoSite-Q80U62
TrEMBL
UniProt Splice Variant
Entrez Gene 100502698
UniGene Mm.402903
RefSeq
MGI ID
MGI Symbol 1700021K19Rik
OMIM
CCDS
HPRD
IMGT
EMBL AC139244 AK030368 AK042428 AK122221 AK170002 AK170223 AK170312 AK171583 BC057307 BC060601 BC067390
GenPept AAH57307 AAH60601 AAH67390 BAC26925 BAC31257 BAC65503 BAE41507 BAE41645 BAE41708 BAE42541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca