InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dclre1c

Summary

InnateDB Protein

IDBP-250435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dclre1c

Protein Name

DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110718

InnateDB Gene

IDBG-133199 (Dclre1c)

Protein Structure

UniProt Annotation

Function

Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein likely exhibits single- strand specific 5'-3' exonuclease activity in isolation, and may acquire endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity may be required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ. {ECO:0000269PubMed:12504013, ECO:0000269PubMed:12615897, ECO:0000269PubMed:15699179}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0008409	5'-3' exonuclease activity
GO:0016787	hydrolase activity

Biological Process

GO:0000723	telomere maintenance
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0010212	response to ionizing radiation
GO:0030183	B cell differentiation
GO:0051276	chromosome organization
GO:0090305	nucleic acid phosphodiester bond hydrolysis