InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aifm1

Summary

InnateDB Protein

IDBP-250692.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Aifm1

Protein Name

apoptosis-inducing factor, mitochondrion-associated 1

Synonyms

AIF; AIFsh2; Hq; Pdcd8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110595

InnateDB Gene

IDBG-143630 (Aifm1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046983	protein dimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0008637	apoptotic mitochondrial changes
GO:0045454	cell redox homeostasis
GO:0051402	neuron apoptotic process
GO:0055114	oxidation-reduction process
GO:1902510	regulation of apoptotic DNA fragmentation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1349419

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
IPR016156 FAD/NAD-linked reductase, dimerisation domain
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF07992

PRINTS

PR00368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite