InnateDB Protein
|
IDBP-250793.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Atp5c1
|
Protein Name
|
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
|
Synonyms
|
1700094F02Rik;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000110547
|
InnateDB Gene
|
IDBG-135543 (Atp5c1)
|
Protein Structure
|
|
Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
|
Subcellular Localization |
Mitochondrion. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
40 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0016887
|
ATPase activity
|
GO:0044822
|
poly(A) RNA binding
|
GO:0046933
|
proton-transporting ATP synthase activity, rotational mechanism
|
GO:0046961
|
proton-transporting ATPase activity, rotational mechanism
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1261437
|
InterPro |
IPR000131
ATPase, F1 complex, gamma subunit
IPR023633
ATPase, F1 complex, gamma subunit domain
|
PFAM |
PF00231
|
PRINTS |
PR00126
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q91VR2
|
PhosphoSite |
PhosphoSite-Q91VR2
|
TrEMBL |
Q8C2Q8
|
UniProt Splice Variant |
|
Entrez Gene |
11949
|
UniGene |
Mm.421630
|
RefSeq |
NP_065640
|
MGI ID |
|
MGI Symbol |
Atp5c1
|
OMIM |
|
CCDS |
CCDS38045
|
HPRD |
|
IMGT |
|
EMBL |
AK088164
AK146434
AK150307
AK158675
AL772367
BC010700
|
GenPept |
AAH10700
BAC40184
BAE27168
BAE29456
BAE34606
|
|
|