InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mbnl3

Summary

InnateDB Protein

IDBP-250851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbnl3

Protein Name

muscleblind-like 3 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110526

InnateDB Gene

IDBG-145022 (Mbnl3)

Protein Structure

UniProt Annotation

Function

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. {ECO:0000250, ECO:0000269PubMed:12297108}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Mostly nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0007275	multicellular organismal development
GO:0008380	RNA splicing
GO:0043484	regulation of RNA splicing
GO:0045662	negative regulation of myoblast differentiation