InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkcq

Summary

InnateDB Protein

IDBP-250884.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Prkcq

Protein Name

protein kinase C, theta

Synonyms

A130035A12Rik; AW494342; PKC-0; PKC-theta; Pkcq; PKCtheta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110503

InnateDB Gene

IDBG-136196 (Prkcq)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004697	protein kinase C activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0042102	positive regulation of T cell proliferation
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0050870	positive regulation of T cell activation

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:97601

InterPro

IPR000008 C2 domain
IPR000719 Protein kinase domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding

PFAM

PF00168
PF00069
PF00130

PRINTS

PR00360
PR00008

PIRSF

SMART

SM00239
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AYX8

UniProt Splice Variant

Entrez Gene

18761

UniGene

Mm.329993

RefSeq

MGI ID

MGI Symbol

Prkcq

OMIM

CCDS

HPRD

IMGT

EMBL

AL928715 AL929020

GenPept