InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cblb

Summary

InnateDB Protein

IDBP-251685.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Cblb

Protein Name

Casitas B-lineage lymphoma b

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110115

InnateDB Gene

IDBG-165705 (Cblb)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0002669	positive regulation of T cell anergy
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0042110	T cell activation
GO:0045732	positive regulation of protein catabolic process
GO:0046642	negative regulation of alpha-beta T cell proliferation
GO:0050860	negative regulation of T cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2146430

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000980 SH2 domain
IPR001841 Zinc finger, RING-type
IPR003153 Adaptor protein Cbl, N-terminal helical
IPR009060 UBA-like
IPR014741 Adaptor protein Cbl, EF hand-like
IPR014742 Adaptor protein Cbl, SH2-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR018957 Zinc finger, C3HC4 RING-type

PFAM