InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcg2

Summary

InnateDB Protein

IDBP-252080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcg2

Protein Name

ATP-binding cassette, sub-family G (WHITE), member 2

Synonyms

ABC15; ABCP; AI428558; BCRP; Bcrp1; MXR; MXR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109933

InnateDB Gene

IDBG-151752 (Abcg2)

Protein Structure

UniProt Annotation

Function

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain (By similarity). May play a role in early stem cell self-renewal by blocking differentiation. {ECO:0000250, ECO:0000269PubMed:10485464, ECO:0000269PubMed:11533706}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in kidney. Lower expression in liver, colon, heart, spleen, and placenta. {ECO:0000269PubMed:11036110}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0015238	drug transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006855	drug transmembrane transport
GO:0010039	response to iron ion
GO:0042908	xenobiotic transport
GO:0046618	drug export
GO:0051384	response to glucocorticoid
GO:0051593	response to folic acid
GO:0060136	embryonic process involved in female pregnancy

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:1347061

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR013525 ABC-2 type transporter
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF01061

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TMS5