InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snca

Summary

InnateDB Protein

IDBP-252137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snca

Protein Name

synuclein, alpha

Synonyms

alphaSYN; NACP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109907

InnateDB Gene

IDBG-152558 (Snca)

Protein Structure

UniProt Annotation

Function

May be involved in the regulation of dopamine release and transport.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	134 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008017	microtubule binding
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0019894	kinesin binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0030544	Hsp70 protein binding
GO:0042393	histone binding
GO:0042802	identical protein binding
GO:0043014	alpha-tubulin binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043274	phospholipase binding
GO:0045502	dynein binding
GO:0047485	protein N-terminus binding
GO:0048156	tau protein binding
GO:0048487	beta-tubulin binding
GO:0050544	arachidonic acid binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001774	microglial cell activation
GO:0001921	positive regulation of receptor recycling
GO:0001933	negative regulation of protein phosphorylation
GO:0001956	positive regulation of neurotransmitter secretion
GO:0001963	synaptic transmission, dopaminergic
GO:0006631	fatty acid metabolic process
GO:0006638	neutral lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006	mitochondrial membrane organization
GO:0007268	synaptic transmission
GO:0007568	aging
GO:0008344	adult locomotory behavior
GO:0010040	response to iron(II) ion
GO:0010517	regulation of phospholipase activity
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048	regulation of glutamate secretion
GO:0014059	regulation of dopamine secretion
GO:0031115	negative regulation of microtubule polymerization
GO:0031623	receptor internalization
GO:0031648	protein destabilization
GO:0032026	response to magnesium ion
GO:0032410	negative regulation of transporter activity
GO:0032496	response to lipopolysaccharide
GO:0032769	negative regulation of monooxygenase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034341	response to interferon-gamma
GO:0034599	cellular response to oxidative stress
GO:0035067	negative regulation of histone acetylation
GO:0040012	regulation of locomotion
GO:0042220	response to cocaine
GO:0042416	dopamine biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0042775	mitochondrial ATP synthesis coupled electron transport
GO:0043030	regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045087	innate immune response (InnateDB)
GO:0045807	positive regulation of endocytosis
GO:0045920	negative regulation of exocytosis
GO:0045963	negative regulation of dopamine metabolic process
GO:0046928	regulation of neurotransmitter secretion
GO:0048148	behavioral response to cocaine
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048488	synaptic vesicle endocytosis
GO:0048489	synaptic vesicle transport
GO:0050806	positive regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050812	regulation of acyl-CoA biosynthetic process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612	negative regulation of serotonin uptake
GO:0051622	negative regulation of norepinephrine uptake
GO:0055114	oxidation-reduction process
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060291	long-term synaptic potentiation
GO:0060732	positive regulation of inositol phosphate biosynthetic process
GO:0061024	membrane organization
GO:0070495	negative regulation of thrombin receptor signaling pathway
GO:0070555	response to interleukin-1
GO:0071280	cellular response to copper ion
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:1901214	regulation of neuron death

Cellular Component

GO:0005634	nucleus
GO:0005640	nuclear outer membrane
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0008021	synaptic vesicle
GO:0015629	actin cytoskeleton
GO:0016234	inclusion body
GO:0030424	axon
GO:0030426	growth cone
GO:0030659	cytoplasmic vesicle membrane
GO:0031092	platelet alpha granule membrane
GO:0043195	terminal bouton
GO:0043205	fibril
GO:0043231	intracellular membrane-bounded organelle
GO:0043679	axon terminus
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm