InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brd2

Summary

InnateDB Protein

IDBP-252176.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brd2

Protein Name

bromodomain containing 2

Synonyms

AW228947; D17H6S113E; Frg-1; Fsrg-1; Fsrg1; mKIAA4005; Nat; Ring3; Rnf3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109880

InnateDB Gene

IDBG-170215 (Brd2)

Protein Structure

UniProt Annotation

Function

Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis. {ECO:0000250, ECO:0000269PubMed:9693039, ECO:0000269PubMed:9811568}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9693039, ECO:0000269PubMed:9811568}. Note=Detected on chromatin and nucleosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in the testis, followed by ovary, placenta, embryo and to a lower extent in somatic tissues. {ECO:0000269PubMed:9693039, ECO:0000269PubMed:9811568}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006334	nucleosome assembly
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016568	chromatin modification