InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cxadr

Summary

InnateDB Protein

IDBP-252204.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxadr

Protein Name

coxsackie virus and adenovirus receptor

Synonyms

2610206D03Rik; AU016810; AW553441; CAR; MCAR; MCVADR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109867

InnateDB Gene

IDBG-171952 (Cxadr)

Protein Structure

UniProt Annotation

Function

Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. {ECO:0000269PubMed:10814828, ECO:0000269PubMed:20813954, ECO:0000269PubMed:9036860, ECO:0000269PubMed:9420240}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Localized at the intercellular contacts. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface (By similarity). {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Localized at the intercellular contacts. In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface (By similarity). {ECO:0000250}.Isoform 3: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver, kidney, heart, lung, and brain. In skeletal muscle is found at the neuromuscular junction. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. {ECO:0000269PubMed:10814828, ECO:0000269PubMed:12763576, ECO:0000269PubMed:15533241, ECO:0000269PubMed:9096397}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0030165	PDZ domain binding
GO:0042802	identical protein binding
GO:0050839	cell adhesion molecule binding
GO:0071253	connexin binding

Biological Process

GO:0007005	mitochondrion organization
GO:0007157	heterophilic cell-cell adhesion
GO:0007507	heart development
GO:0008354	germ cell migration
GO:0010669	epithelial structure maintenance
GO:0016337	single organismal cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0031532	actin cytoskeleton reorganization
GO:0034109	homotypic cell-cell adhesion
GO:0045216	cell-cell junction organization
GO:0046629	gamma-delta T cell activation
GO:0048739	cardiac muscle fiber development
GO:0051607	defense response to virus
GO:0060044	negative regulation of cardiac muscle cell proliferation
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0070633	transepithelial transport
GO:0086067	AV node cell to bundle of His cell communication

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0014704	intercalated disc
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030175	filopodium
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0043234	protein complex
GO:0044297	cell body
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:1201679

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain

PFAM

PF07679
PF07686

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97792