InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsc1

Summary

InnateDB Protein

IDBP-252963.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsc1

Protein Name

tuberous sclerosis 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109498

InnateDB Gene

IDBG-152579 (Tsc1)

Protein Structure

UniProt Annotation

Function

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=At steady state found in association with membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0030695	GTPase regulator activity
GO:0032794	GTPase activating protein binding
GO:0047485	protein N-terminus binding
GO:0051087	chaperone binding

Biological Process

GO:0001822	kidney development
GO:0001843	neural tube closure
GO:0006407	rRNA export from nucleus
GO:0006813	potassium ion transport
GO:0007160	cell-matrix adhesion
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0017148	negative regulation of translation
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0030030	cell projection organization
GO:0032007	negative regulation of TOR signaling
GO:0032318	regulation of Ras GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0032868	response to insulin
GO:0032956	regulation of actin cytoskeleton organization
GO:0042552	myelination
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0045087	innate immune response (InnateDB)
GO:0045792	negative regulation of cell size
GO:0045859	regulation of protein kinase activity
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050808	synapse organization
GO:0050821	protein stabilization
GO:0051291	protein heterooligomerization
GO:0051492	regulation of stress fiber assembly
GO:0051726	regulation of cell cycle
GO:0051894	positive regulation of focal adhesion assembly
GO:0055007	cardiac muscle cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0033596	TSC1-TSC2 complex
GO:0043231	intracellular membrane-bounded organelle