InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eda2r

Summary

InnateDB Protein

IDBP-253053.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eda2r

Protein Name

ectodysplasin A2 receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109463

InnateDB Gene

IDBG-161374 (Eda2r)

Protein Structure

UniProt Annotation

Function

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007275	multicellular organismal development
GO:0012501	programmed cell death
GO:0030154	cell differentiation
GO:0046330	positive regulation of JNK cascade
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator