InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcx

Summary

InnateDB Protein

IDBP-253072.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcx

Protein Name

pyruvate carboxylase

Synonyms

Pc; Pcb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109456

InnateDB Gene

IDBG-129649 (Pcx)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004075	biotin carboxylase activity
GO:0004736	pyruvate carboxylase activity
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0009374	biotin binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006094	gluconeogenesis
GO:0006107	oxaloacetate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:97520

InterPro

IPR000089 Biotin/lipoyl attachment
IPR000891 Pyruvate carboxyltransferase
IPR003379 Carboxylase, conserved domain
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR005930 Pyruvate carboxylase
IPR011053 Single hybrid motif
IPR011054 Rudiment single hybrid motif
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011761 ATP-grasp fold
IPR011764 Biotin carboxylation domain
IPR016185 Pre-ATP-grasp domain

PFAM