InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eda

Summary

InnateDB Protein

IDBP-253148.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Eda

Protein Name

ectodysplasin-A

Synonyms

Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby; XLHED;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109413

InnateDB Gene

IDBG-161929 (Eda)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0006955	immune response
GO:0007160	cell-matrix adhesion
GO:0010467	gene expression
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043473	pigmentation
GO:0043588	skin development
GO:0060662	salivary gland cavitation
GO:0060789	hair follicle placode formation
GO:0061153	trachea gland development
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0045177	apical part of cell

Protein Structure and Domains

PDB ID

MGI:1195272

InterPro

IPR006052 Tumour necrosis factor domain
IPR008160 Collagen triple helix repeat
IPR008983 Tumour necrosis factor-like domain

PFAM

PF00229
PF01391

PRINTS

PIRSF

SMART

SM00207

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q1L2D9

UniProt Splice Variant

Entrez Gene

13607

UniGene

Mm.328086

RefSeq

MGI ID

MGI Symbol

Eda

OMIM

CCDS

HPRD

IMGT

EMBL

AL671299 AL671979 AL773561 BX005452 BX890547 DQ168878

GenPept

ABB59618