InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eda

Summary

InnateDB Protein

IDBP-253152.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eda

Protein Name

ectodysplasin-A

Synonyms

Ed1; Eda-A1; Eda-A2; EDA1; HED; Ta; tabby; XLHED;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109410

InnateDB Gene

IDBG-161929 (Eda)

Protein Structure

UniProt Annotation

Function

Involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor XEDAR.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Ectodysplasin-A, secreted form: Secreted {ECO:0000250}.

Disease Associations

Note=Defects in Eda are the cause of the tabby phenotype in mice (the equivalent of anhidrotic ectodermal dysplasia in humans). The disease is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001942	hair follicle development
GO:0006955	immune response
GO:0007160	cell-matrix adhesion
GO:0010467	gene expression
GO:0030154	cell differentiation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043473	pigmentation
GO:0043588	skin development
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060662	salivary gland cavitation
GO:0060789	hair follicle placode formation
GO:0061153	trachea gland development
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0045177	apical part of cell