Version 5.4
Homo sapiens Protein: RPRD1A
Summary
InnateDB Protein IDBP-2535.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPRD1A
Protein Name regulation of nuclear pre-mRNA domain containing 1A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000349955
InnateDB Gene IDBG-2531 (RPRD1A)
Protein Structure
UniProt Annotation
Function Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269PubMed:22231121}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain
Cellular Component
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
Protein Structure and Domains
PDB ID
InterPro IPR006569 CID domain
IPR006903 RNA polymerase II-binding domain
IPR008942 ENTH/VHS
PFAM PF04818
PRINTS
PIRSF
SMART SM00582
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96P16
PhosphoSite PhosphoSite-Q96P16
TrEMBL K7ER50
UniProt Splice Variant
Entrez Gene 55197
UniGene Hs.645628
RefSeq
HUGO HGNC:25560
OMIM 610347
CCDS CCDS11917
HPRD 10134
IMGT
EMBL AC091060 AF419845 AK001518 AK292907 AK314569 BC000225 BC010136 CH471088
GenPept AAH00225 AAH10136 AAL15972 BAA91736 BAF85596 BAG37150 EAX01365 EAX01366 EAX01367 EAX01368 EAX01369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca