InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc22a12

Summary

InnateDB Protein

IDBP-253846.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a12

Protein Name

solute carrier family 22 (organic anion/cation transporter), member 12

Synonyms

AI987855; OAT4L; Rst; Slc22al2; URAT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109078

InnateDB Gene

IDBG-136697 (Slc22a12)

Protein Structure

UniProt Annotation

Function

Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions. {ECO:0000269PubMed:14747372}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14747372}; Multi-pass membrane protein {ECO:0000269PubMed:14747372}. Note=Detected in the luminal membrane of the epithelium of renal proximal tubules.

Disease Associations

Tissue Specificity

Detected in kidney (at protein level). Detected in kidney cortex, in proximal tubules. {ECO:0000269PubMed:14747372, ECO:0000269PubMed:9409754}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015143	urate transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0030165	PDZ domain binding

Biological Process

GO:0015747	urate transport
GO:0015849	organic acid transport
GO:0042493	response to drug
GO:0046415	urate metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1195269

InterPro

IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF00083
PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CFZ5

PhosphoSite