InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ak1

Summary

InnateDB Protein

IDBP-254225.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak1

Protein Name

adenylate kinase 1

Synonyms

Ak-1; B430205N08Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108903

InnateDB Gene

IDBG-160744 (Ak1)

Protein Structure

UniProt Annotation

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also possesses broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility. {ECO:0000250, ECO:0000269PubMed:16790685}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03171}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0019205	nucleobase-containing compound kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0007050	cell cycle arrest
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0016310	phosphorylation
GO:0046034	ATP metabolic process