InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nox1

Summary

InnateDB Protein

IDBP-254229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nox1

Protein Name

NADPH oxidase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108900

InnateDB Gene

IDBG-170699 (Nox1)

Protein Structure

UniProt Annotation

Function

Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. {ECO:0000269PubMed:16724959}.

Subcellular Localization

Cell projection, invadopodium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 2 expressed in colon and vascular smooth muscle cells (VSMC). {ECO:0000269PubMed:16724959}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0030171	voltage-gated proton channel activity
GO:0046872	metal ion binding
GO:0048365	Rac GTPase binding

Biological Process

GO:0001525	angiogenesis
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0008284	positive regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0015992	proton transport
GO:0016477	cell migration
GO:0030198	extracellular matrix organization
GO:0042554	superoxide anion generation
GO:0042743	hydrogen peroxide metabolic process
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045726	positive regulation of integrin biosynthetic process
GO:0046330	positive regulation of JNK cascade
GO:0051454	intracellular pH elevation
GO:0055114	oxidation-reduction process
GO:0071455	cellular response to hyperoxia
GO:0071468	cellular response to acidity
GO:0072592	oxygen metabolic process
GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0030054	cell junction
GO:0043020	NADPH oxidase complex
GO:0071438	invadopodium membrane

Protein Structure and Domains

PDB ID

MGI:2450016

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CIZ9