Version 5.4
Mus musculus Protein: Crbn
Summary
InnateDB Protein IDBP-254295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crbn
Protein Name cereblon
Synonyms 2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL;
Species Mus musculus
Ensembl Protein ENSMUSP00000108865
InnateDB Gene IDBG-174064 (Crbn)
Protein Structure
UniProt Annotation
Function Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in brain. {ECO:0000269PubMed:20131966}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006508 proteolysis
GO:0016567 protein ubiquitination
GO:0032463 negative regulation of protein homooligomerization
GO:0034766 negative regulation of ion transmembrane transport
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0090073 positive regulation of protein homodimerization activity
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1913277
InterPro IPR003111 Peptidase S16, lon N-terminal
IPR015947 PUA-like domain
PFAM PF02190
PRINTS
PIRSF
SMART SM00464
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C7D2
PhosphoSite PhosphoSite-Q8C7D2
TrEMBL
UniProt Splice Variant
Entrez Gene 58799
UniGene Mm.290085
RefSeq
MGI ID
MGI Symbol Crbn
OMIM
CCDS CCDS39583
HPRD
IMGT
EMBL AF229032 AK050557 AK076144 AK077707 AK160219 BC046967 BC069905 BC086488
GenPept AAF35895 AAH46967 AAH69905 AAH86488 BAC34322 BAC36214 BAC36970 BAE35697

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca