Version 5.4
Mus musculus Protein: Bex1
Summary
InnateDB Protein IDBP-254566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bex1
Protein Name brain expressed gene 1
Synonyms AA407839; AU018692; Bex4; Rex3;
Species Mus musculus
Ensembl Protein ENSMUSP00000108743
InnateDB Gene IDBG-173033 (Bex1)
Protein Structure
UniProt Annotation
Function Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12911636}. Cytoplasm {ECO:0000269PubMed:12911636}. Note=Shuttles between the cytoplasm and the nucleus.
Disease Associations
Tissue Specificity Primarily localized to neuronal cells within several regions of the brain, including the olfactory epithelium, bulb, peri/paraventricular nuclei, suprachiasmatic nucleus, arcuate nucleus, median eminence, lateral hypothalamic area, thalamus, hippocampus and cerebellum (at protein level). Expressed in brain, mid term embryos and to a lesser extent in ovary. In testis, it is expressed in the pachytene spermatocytes and spermatids but not in spermatogonia. {ECO:0000269PubMed:10072429, ECO:0000269PubMed:11989783, ECO:0000269PubMed:15861462, ECO:0000269PubMed:9806360}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0030154 cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1328321
InterPro IPR007623 Brain-expressed X-linked protein
IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like
PFAM PF04538
PRINTS
PIRSF PIRSF008633
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9R224
PhosphoSite PhosphoSite-Q9R224
TrEMBL
UniProt Splice Variant
Entrez Gene 19716
UniGene
RefSeq
MGI ID
MGI Symbol Bex1
OMIM
CCDS CCDS30417
HPRD
IMGT
EMBL AF051347 AF097437 AF097438 AL671493 BC061179 BC089464 CH466616
GenPept AAC61929 AAD24429 AAD47168 AAH61179 AAH89464 CAM45858 EDL23851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca