InnateDB Protein
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IDBP-254617.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cidec
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Protein Name
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cell death-inducing DFFA-like effector c
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Synonyms
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CIDE-3; Fsp27;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108712
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InnateDB Gene
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IDBG-176827 (Cidec)
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Protein Structure
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Function |
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression. {ECO:0000269PubMed:18334488, ECO:0000269PubMed:22144693, ECO:0000269PubMed:22245780, ECO:0000269PubMed:23481402}.
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Subcellular Localization |
Lipid droplet. Endoplasmic reticulum. Nucleus. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
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Disease Associations |
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Tissue Specificity |
Expressed almost exclusively in adipose tissue, including subcutaneous and epididymal white adipose tissue (at protein level). Although abundantly present in brown adipose tissue at the mRNA level, the protein is almost undetectable in this tissue (PubMed:18654663), or at moderate levels (PubMed:22245780, PubMed:12910269). Expressed in the mammary gland, in stromal adipose tissue, but becomes undetectable at the end of pregnancy and during lactation (at protein level). Expressed at low levels in skeletal muscle and heart. {ECO:0000269PubMed:12910269, ECO:0000269PubMed:1339452, ECO:0000269PubMed:18654663, ECO:0000269PubMed:22245780, ECO:0000269PubMed:23233732}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95585
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InterPro |
IPR003508
CIDE-N domain
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PFAM |
PF02017
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PRINTS |
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PIRSF |
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SMART |
SM00266
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TIGRFAMs |
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Modification |
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SwissProt |
P56198
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PhosphoSite |
PhosphoSite-P56198
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TrEMBL |
D3Z1A6
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UniProt Splice Variant |
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Entrez Gene |
14311
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UniGene |
Mm.10026
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RefSeq |
XP_006505594
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MGI ID |
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MGI Symbol |
Cidec
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OMIM |
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CCDS |
CCDS20418
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HPRD |
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IMGT |
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EMBL |
AC153910
AK080133
BC099676
M61737
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GenPept |
AAH99676
BAC37830
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