Version 5.4
Homo sapiens Protein: TMED3
Summary
InnateDB Protein IDBP-25468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMED3
Protein Name transmembrane emp24 protein transport domain containing 3
Synonyms C15orf22; P24B; p26;
Species Homo sapiens
Ensembl Protein ENSP00000299705
InnateDB Gene IDBG-25466 (TMED3)
Protein Structure
UniProt Annotation
Function Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. {ECO:0000269PubMed:10852829}.
Subcellular Localization Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Probably cycles between compartments of the early secretatory pathway.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
GO:0015031 protein transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030126 COPI vesicle coat
GO:0032580 Golgi cisterna membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
Protein Structure and Domains
PDB ID
InterPro IPR009038 GOLD
PFAM PF01105
PF13897
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y3Q3
PhosphoSite PhosphoSite-Q9Y3Q3
TrEMBL Q9UMB6
UniProt Splice Variant
Entrez Gene 23423
UniGene Hs.714066
RefSeq NP_031390
HUGO HGNC:28889
OMIM
CCDS CCDS10310
HPRD 18200
IMGT
EMBL AC011797 AC027811 AJ132270 AK289434 AK297710 AL109672 AL109673 AY358974 BC000027 BC010853 BC017495 BC022232 BC111547 CR457384
GenPept AAH00027 AAH10853 AAH17495 AAH22232 AAI11548 AAQ89333 BAF82123 BAG60067 CAB40416 CAB52017 CAB52018 CAG33665

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca