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InnateDB Protein
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IDBP-254858.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atg4a
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Protein Name
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autophagy-related 4A (yeast)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108595
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InnateDB Gene
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IDBG-254856 (Atg4a)
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Protein Structure
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| Function |
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
2 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0004197
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cysteine-type endopeptidase activity
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GO:0008234
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cysteine-type peptidase activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:2147903
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| InterPro |
IPR005078
Peptidase C54
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| PFAM |
PF03416
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8C9S8
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
Q5EBK1
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| UniProt Splice Variant |
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| Entrez Gene |
666468
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| UniGene |
Mm.393320
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| RefSeq |
NP_777364
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| MGI ID |
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| MGI Symbol |
Atg4a
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AJ504654
AK041379
AK162404
BC089500
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| GenPept |
AAH89500
BAC30924
BAE36898
CAD43221
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Version 5.4