InnateDB Protein
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IDBP-254937.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cntf
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Protein Name
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ciliary neurotrophic factor
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Synonyms
|
AI429687;
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Species
|
Mus musculus
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Ensembl Protein
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ENSMUSP00000108555
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InnateDB Gene
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IDBG-254935 (Cntf)
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Protein Structure
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|
Function |
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Nervous system.
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Comments |
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Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
|
DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
11 [view]
|
|
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Molecular Function |
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Biological Process |
GO:0008284
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positive regulation of cell proliferation
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GO:0040007
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growth
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GO:0042517
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positive regulation of tyrosine phosphorylation of Stat3 protein
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0046533
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negative regulation of photoreceptor cell differentiation
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GO:0046668
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regulation of retinal cell programmed cell death
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GO:0048644
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muscle organ morphogenesis
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GO:0048666
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neuron development
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GO:0070120
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ciliary neurotrophic factor-mediated signaling pathway
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Cellular Component |
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PDB ID |
MGI:88439
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InterPro |
IPR000151
Ciliary neurotrophic factor, CNTF
IPR009079
Four-helical cytokine-like, core
|
PFAM |
PF01110
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PRINTS |
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PIRSF |
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SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P51642
|
PhosphoSite |
PhosphoSite-P51642
|
TrEMBL |
Q544D1
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UniProt Splice Variant |
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Entrez Gene |
12803
|
UniGene |
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RefSeq |
NP_740756
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MGI ID |
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MGI Symbol |
Cntf
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OMIM |
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CCDS |
CCDS29637
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HPRD |
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IMGT |
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EMBL |
AK041204
BC027539
CH466534
U05342
|
GenPept |
AAA81912
AAH27539
BAC30862
EDL41483
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