InnateDB Protein
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IDBP-254945.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ift122
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Protein Name
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intraflagellar transport 122 homolog (Chlamydomonas)
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Synonyms
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C86139; sopb; Wdr10;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108547
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InnateDB Gene
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IDBG-179708 (Ift122)
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Protein Structure
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Function |
Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia. {ECO:0000269PubMed:19000668, ECO:0000269PubMed:21209331}.
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Subcellular Localization |
Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to photoreceptor connecting cilia.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0001843
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neural tube closure
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GO:0007227
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signal transduction downstream of smoothened
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GO:0009953
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dorsal/ventral pattern formation
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GO:0010172
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embryonic body morphogenesis
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GO:0021914
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negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
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GO:0035050
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embryonic heart tube development
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GO:0035115
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embryonic forelimb morphogenesis
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GO:0035720
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intraciliary anterograde transport
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GO:0035721
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intraciliary retrograde transport
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GO:0042733
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embryonic digit morphogenesis
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GO:0045879
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negative regulation of smoothened signaling pathway
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GO:0048593
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camera-type eye morphogenesis
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GO:0050680
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negative regulation of epithelial cell proliferation
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GO:0060173
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limb development
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GO:0060271
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cilium morphogenesis
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GO:0060830
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ciliary receptor clustering involved in smoothened signaling pathway
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GO:0060831
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smoothened signaling pathway involved in dorsal/ventral neural tube patterning
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GO:0060971
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embryonic heart tube left/right pattern formation
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GO:0072594
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establishment of protein localization to organelle
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Cellular Component |
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PDB ID |
MGI:1932386
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InterPro |
IPR001680
WD40 repeat
IPR017986
WD40-repeat-containing domain
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PFAM |
PF00400
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PRINTS |
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PIRSF |
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SMART |
SM00320
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NWV3
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PhosphoSite |
PhosphoSite-Q6NWV3
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TrEMBL |
Q9ERM4
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UniProt Splice Variant |
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Entrez Gene |
81896
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UniGene |
Mm.333335
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RefSeq |
NP_001161235
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MGI ID |
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MGI Symbol |
Ift122
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OMIM |
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CCDS |
CCDS51880
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HPRD |
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IMGT |
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EMBL |
AF296075
AK031308
AK044456
AK077104
AK131115
AK167330
AK167412
BC066083
BC067415
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GenPept |
AAG15251
AAH66083
AAH67415
BAC27340
BAC31930
BAC36613
BAD21365
BAE39432
BAE39501
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