InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgap15

Summary

InnateDB Protein

IDBP-255172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap15

Protein Name

Rho GTPase activating protein 15

Synonyms

5830480G12Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108441

InnateDB Gene

IDBG-168042 (Arhgap15)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0008360	regulation of cell shape
GO:0032855	positive regulation of Rac GTPase activity
GO:0045087	innate immune response (InnateDB)