InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcl2

Summary

InnateDB Protein

IDBP-255358.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl2

Protein Name

B-cell leukemia/lymphoma 2

Synonyms

AW986256; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108371

InnateDB Gene

IDBG-185673 (Bcl2)

Protein Structure

UniProt Annotation

Function

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Subcellular Localization

Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	47 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0015267	channel activity
GO:0016248	channel inhibitor activity
GO:0019903	protein phosphatase binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0000902	cell morphogenesis
GO:0001101	response to acid
GO:0001503	ossification
GO:0001541	ovarian follicle development
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001662	behavioral fear response
GO:0001776	leukocyte homeostasis
GO:0001782	B cell homeostasis
GO:0001822	kidney development
GO:0001836	release of cytochrome c from mitochondria
GO:0001952	regulation of cell-matrix adhesion
GO:0002260	lymphocyte homeostasis
GO:0002320	lymphoid progenitor cell differentiation
GO:0002326	B cell lineage commitment
GO:0002360	T cell lineage commitment
GO:0002520	immune system development
GO:0002931	response to ischemia
GO:0003014	renal system process
GO:0006470	protein dephosphorylation
GO:0006582	melanin metabolic process
GO:0006808	regulation of nitrogen utilization
GO:0006874	cellular calcium ion homeostasis
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007015	actin filament organization
GO:0007409	axonogenesis
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0009636	response to toxic substance
GO:0009791	post-embryonic development
GO:0009887	organ morphogenesis
GO:0010039	response to iron ion
GO:0010224	response to UV-B
GO:0010332	response to gamma radiation
GO:0010468	regulation of gene expression
GO:0010523	negative regulation of calcium ion transport into cytosol
GO:0010559	regulation of glycoprotein biosynthetic process
GO:0014031	mesenchymal cell development
GO:0014042	positive regulation of neuron maturation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016049	cell growth
GO:0016337	single organismal cell-cell adhesion
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0021747	cochlear nucleus development
GO:0022612	gland morphogenesis
GO:0022898	regulation of transmembrane transporter activity
GO:0030097	hemopoiesis
GO:0030183	B cell differentiation
GO:0030217	T cell differentiation
GO:0030279	negative regulation of ossification
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030318	melanocyte differentiation
GO:0030336	negative regulation of cell migration
GO:0030890	positive regulation of B cell proliferation
GO:0031069	hair follicle morphogenesis
GO:0031103	axon regeneration
GO:0031647	regulation of protein stability
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0032835	glomerulus development
GO:0032848	negative regulation of cellular pH reduction
GO:0032880	regulation of protein localization
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0033077	T cell differentiation in thymus
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033689	negative regulation of osteoblast proliferation
GO:0034097	response to cytokine
GO:0035094	response to nicotine
GO:0035265	organ growth
GO:0040007	growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042100	B cell proliferation
GO:0042149	cellular response to glucose starvation
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042981	regulation of apoptotic process
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043067	regulation of programmed cell death
GO:0043085	positive regulation of catalytic activity
GO:0043375	CD8-positive, alpha-beta T cell lineage commitment
GO:0043473	pigmentation
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0043524	negative regulation of neuron apoptotic process
GO:0043583	ear development
GO:0045069	regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045636	positive regulation of melanocyte differentiation
GO:0045930	negative regulation of mitotic cell cycle
GO:0046671	negative regulation of retinal cell programmed cell death
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048041	focal adhesion assembly
GO:0048066	developmental pigmentation
GO:0048070	regulation of developmental pigmentation
GO:0048087	positive regulation of developmental pigmentation
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048545	response to steroid hormone
GO:0048546	digestive tract morphogenesis
GO:0048589	developmental growth
GO:0048599	oocyte development
GO:0048743	positive regulation of skeletal muscle fiber development
GO:0048753	pigment granule organization
GO:0048873	homeostasis of number of cells within a tissue
GO:0050790	regulation of catalytic activity
GO:0050853	B cell receptor signaling pathway
GO:0051384	response to glucocorticoid
GO:0051402	neuron apoptotic process
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle
GO:0051881	regulation of mitochondrial membrane potential
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071310	cellular response to organic substance
GO:0071456	cellular response to hypoxia
GO:0072593	reactive oxygen species metabolic process
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
GO:2000811	negative regulation of anoikis
GO:2001234	negative regulation of apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0031966	mitochondrial membrane
GO:0043209	myelin sheath
GO:0046930	pore complex

Protein Structure and Domains

PDB ID

MGI:88138

InterPro

IPR002475 Bcl2-like
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4
IPR004725 Apoptosis regulator, Bcl-2/ BclX
IPR013278 Apoptosis regulator, Bcl-2
IPR013279 Apoptosis regulator, Bcl-X
IPR026298 Blc2 family

PFAM

PF02180
PF00452

PRINTS

PR01863
PR01864
PR01862

PIRSF

SMART

SM00265

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt