Mus musculus Protein: Huwe1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-255548.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Huwe1 | ||||||||||||||||||||||
Protein Name | HECT, UBA and WWE domain containing 1 | ||||||||||||||||||||||
Synonyms | 5430439H10Rik; Arf-bp1; AU041296; C430014N20Rik; C80292; Gm1718; Ib772; LASU1; Mule; Ureb1; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000108241 | ||||||||||||||||||||||
InnateDB Gene | IDBG-179321 (Huwe1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:17823942}. Nucleus {ECO:0000269PubMed:17823942}. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Widely expressed. {ECO:0000269PubMed:17823942}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1926884 | ||||||||||||||||||||||
InterPro |
IPR000449
Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal IPR000569 HECT IPR004170 WWE domain IPR009060 UBA-like IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908 IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913 IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote IPR016024 Armadillo-type fold |
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PFAM |
PF00627
PF00632 PF02825 PF06012 PF06025 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00119
SM00165 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q7TMY8 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q7TMY8 | ||||||||||||||||||||||
TrEMBL | Q3TL29 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 59026 | ||||||||||||||||||||||
UniGene | Mm.488413 | ||||||||||||||||||||||
RefSeq | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Huwe1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB025966 AB093227 AK083499 AK166712 AL672180 AL954855 AY772010 AY929611 BC011391 BC017642 BC054372 BC070444 BX571795 | ||||||||||||||||||||||
GenPept | AAH11391 AAH17642 AAH54372 AAH70444 AAV90839 AAX24124 BAA84697 BAC38936 BAC41411 BAE38964 CAM13774 CAM17616 CAM23826 | ||||||||||||||||||||||