Version 5.4
Mus musculus Protein: Rpap2
Summary
InnateDB Protein IDBP-255563.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rpap2
Protein Name RNA polymerase II associated protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000108270
InnateDB Gene IDBG-187173 (Rpap2)
Protein Structure
UniProt Annotation
Function Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008420 CTD phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0009301 snRNA transcription
GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
Protein Structure and Domains
PDB ID MGI:2141142
InterPro IPR007308 Protein of unknown function DUF408
PFAM PF04181
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VC34
PhosphoSite PhosphoSite-Q8VC34
TrEMBL
UniProt Splice Variant
Entrez Gene 231571
UniGene Mm.482420
RefSeq NP_001276498
MGI ID
MGI Symbol Rpap2
OMIM
CCDS CCDS71631
HPRD
IMGT
EMBL AK034418 AK049889 AK145830 AK161901 AK166574 BC021895
GenPept AAH21895 BAC28703 BAC33973 BAE26681 BAE36627 BAE38864

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca