InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Steap3

Summary

InnateDB Protein

IDBP-255588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Steap3

Protein Name

STEAP family member 3

Synonyms

1010001D01Rik; pHyde; Tsap6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108260

InnateDB Gene

IDBG-188010 (Steap3)

Protein Structure

UniProt Annotation

Function

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269PubMed:16227996, ECO:0000269PubMed:16609065}.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:16227996}; Multi-pass membrane protein {ECO:0000269PubMed:16227996}.

Disease Associations

Tissue Specificity

Highly expressed in fetal liver (the site of midgestational hematopoiesis). {ECO:0000269PubMed:12606722, ECO:0000269PubMed:16227996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000293	ferric-chelate reductase activity
GO:0005515	protein binding
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006826	iron ion transport
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0009306	protein secretion
GO:0015677	copper ion import
GO:0043065	positive regulation of apoptotic process
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990182	exosomal secretion