InnateDB Protein
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IDBP-255590.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Steap3
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Protein Name
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STEAP family member 3
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Synonyms
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1010001D01Rik; pHyde; Tsap6;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108259
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InnateDB Gene
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IDBG-188010 (Steap3)
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Protein Structure
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Function |
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269PubMed:16227996, ECO:0000269PubMed:16609065}.
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Subcellular Localization |
Endosome membrane {ECO:0000269PubMed:16227996}; Multi-pass membrane protein {ECO:0000269PubMed:16227996}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in fetal liver (the site of midgestational hematopoiesis). {ECO:0000269PubMed:12606722, ECO:0000269PubMed:16227996}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915678
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InterPro |
IPR013130
Ferric reductase transmembrane component-like domain
IPR028939
Pyrroline-5-carboxylate reductase, catalytic, N-terminal
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PFAM |
PF01794
PF03807
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CI59
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PhosphoSite |
PhosphoSite-Q8CI59
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68428
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UniGene |
Mm.181033
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RefSeq |
NP_573449
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MGI ID |
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MGI Symbol |
Steap3
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OMIM |
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CCDS |
CCDS48343
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HPRD |
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IMGT |
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EMBL |
AK078769
AK167028
AK171237
AY029586
AY214462
BC037435
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GenPept |
AAH37435
AAK50539
AAO38239
BAC37383
BAE39201
BAE42333
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