InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Steap3

Summary

InnateDB Protein

IDBP-255592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Steap3

Protein Name

STEAP family member 3

Synonyms

1010001D01Rik; pHyde; Tsap6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108258

InnateDB Gene

IDBG-188010 (Steap3)

Protein Structure

UniProt Annotation

Function

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. {ECO:0000269PubMed:16227996, ECO:0000269PubMed:16609065}.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:16227996}; Multi-pass membrane protein {ECO:0000269PubMed:16227996}.

Disease Associations

Tissue Specificity

Highly expressed in fetal liver (the site of midgestational hematopoiesis). {ECO:0000269PubMed:12606722, ECO:0000269PubMed:16227996}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000293	ferric-chelate reductase activity
GO:0008823	cupric reductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006826	iron ion transport
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0009306	protein secretion
GO:0015677	copper ion import
GO:0043065	positive regulation of apoptotic process
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:1990182	exosomal secretion

Cellular Component

GO:0005768	endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1915678

InterPro

IPR013130 Ferric reductase transmembrane component-like domain
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF01794
PF03807

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CI59

PhosphoSite

PhosphoSite-Q8CI59

TrEMBL

UniProt Splice Variant

Entrez Gene

68428

UniGene

Mm.181033

RefSeq

MGI ID

MGI Symbol

Steap3

OMIM

CCDS

CCDS48343

HPRD

IMGT

EMBL

AK078769 AK167028 AK171237 AY029586 AY214462 BC037435

GenPept

AAH37435 AAK50539 AAO38239 BAC37383 BAE39201 BAE42333