Version 5.4
| Mus musculus Protein: Galnt13 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-255600.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Galnt13 | ||||||
| Protein Name | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000108253 | ||||||
| InnateDB Gene | IDBG-171430 (Galnt13) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. Probably responsible for the synthesis of Tn antigen in neuronal cells. {ECO:0000269PubMed:12407114, ECO:0000269PubMed:8618846}. | ||||||
| Subcellular Localization | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Specifically expressed in neuronal cells. Not expressed in glial cells such as astrocytes. Expressed at low level. {ECO:0000269PubMed:12407114, ECO:0000269PubMed:12651884}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:2139447 | ||||||
| InterPro |
IPR000772
Ricin B lectin domain IPR001173 Glycosyltransferase 2-like IPR029044 Nucleotide-diphospho-sugar transferases |
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| PFAM |
PF00652
PF14200 PF00535 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00458
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q8CF93 | ||||||
| PhosphoSite | PhosphoSite-Q8CF93 | ||||||
| TrEMBL | B1AY79 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 271786 | ||||||
| UniGene | Mm.487482 | ||||||
| RefSeq | |||||||
| MGI ID | |||||||
| MGI Symbol | Galnt13 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AB082928 AK038387 AK045417 AL844865 AL844895 AL845426 AL929113 BX321901 | ||||||
| GenPept | BAC29981 BAC32353 BAC54546 | ||||||