Version 5.4
Mus musculus Protein: Dpy30
Summary
InnateDB Protein IDBP-255738.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dpy30
Protein Name dpy-30 homolog (C. elegans)
Synonyms 2810410M20Rik; C87842;
Species Mus musculus
Ensembl Protein ENSMUSP00000108190
InnateDB Gene IDBG-197758 (Dpy30)
Protein Structure
UniProt Annotation
Function As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys- 4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play an indirect or direct role in endosomal transport. {ECO:0000269PubMed:21335234}.
Subcellular Localization Nucleus {ECO:0000269PubMed:21335234}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Associated with chromatin at regions enriched in histone H3 trimethylated at 'Lys- 4'. Highly enriched in gene promoter regions and 5' UTRs, but not in downstream regions of genes or 3' UTRs.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016197 endosomal transport
GO:0051568 histone H3-K4 methylation
Cellular Component
GO:0005634 nucleus
GO:0005802 trans-Golgi network
GO:0035097 histone methyltransferase complex
GO:0048188 Set1C/COMPASS complex
Protein Structure and Domains
PDB ID MGI:1913560
InterPro IPR007858 Dpy-30 motif
PFAM PF05186
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99LT0
PhosphoSite PhosphoSite-Q99LT0
TrEMBL
UniProt Splice Variant
Entrez Gene 66310
UniGene Mm.471983
RefSeq NP_001139695
MGI ID
MGI Symbol Dpy30
OMIM
CCDS CCDS28970
HPRD
IMGT
EMBL AK003688 AK011643 AK013073 AK077902 BC002240
GenPept AAH02240 BAC25047 BAC25341 BAC25389 BAC37054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca