InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rps6ka3

Summary

InnateDB Protein

IDBP-255868.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Rps6ka3

Protein Name

ribosomal protein S6 kinase polypeptide 3

Synonyms

C130006E23; MAPKAPK-1b; MPK-9; p90RSK3; pp90RSK2; Rsk2; S6K-alpha3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108112

InnateDB Gene

IDBG-182115 (Rps6ka3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

MGI:104557

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

B1AXN9

UniProt Splice Variant

Entrez Gene

110651

UniGene

Mm.392829

RefSeq

MGI ID

MGI Symbol

Rps6ka3

OMIM

CCDS

HPRD

IMGT

EMBL

AL671881 AL808146

GenPept