InnateDB Protein
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IDBP-255886.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tank
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Protein Name
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TRAF family member-associated Nf-kappa B activator
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Synonyms
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C86182; E430026L09Rik; I-TRAF;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108120
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InnateDB Gene
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IDBG-173742 (Tank)
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Protein Structure
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Function |
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
Heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated |
Total |
23
[view]
|
Protein-Protein |
23
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
60 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107676
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P70347
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PhosphoSite |
PhosphoSite-P70347
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21353
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UniGene |
Mm.465720
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RefSeq |
NP_001157543
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MGI ID |
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MGI Symbol |
Tank
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OMIM |
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CCDS |
CCDS50592
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HPRD |
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IMGT |
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EMBL |
U51907
U59864
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GenPept |
AAB02204
AAC52781
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