InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fas

Summary

InnateDB Protein

IDBP-255938.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Fas

Protein Name

Fas (TNF receptor superfamily member 6)

Synonyms

AI196731; APO1; APT1; CD95; lpr; TNFR6; Tnfrsf6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108091

InnateDB Gene

IDBG-159577 (Fas)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002377	immunoglobulin production
GO:0003014	renal system process
GO:0006915	apoptotic process
GO:0006924	activation-induced cell death of T cells
GO:0006925	inflammatory cell apoptotic process
GO:0006927	transformed cell apoptotic process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009636	response to toxic substance
GO:0010467	gene expression
GO:0019724	B cell mediated immunity
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0045060	negative thymic T cell selection
GO:0045619	regulation of lymphocyte differentiation
GO:0045637	regulation of myeloid cell differentiation
GO:0048536	spleen development
GO:0050869	negative regulation of B cell activation
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0051402	neuron apoptotic process
GO:0071285	cellular response to lithium ion
GO:0097049	motor neuron apoptotic process
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097527	necroptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand